Exposure‐Based Validation List for Developmental Toxicity Screening Assays
نویسندگان
چکیده
منابع مشابه
Screening for developmental toxicity of tobacco smoke constituents.
Cigarette smoking is unrivaled among developmental toxicants in terms of total adverse impact on the human population. According to the American Lung Association, smoking during pregnancy is estimated to account for 20–30% of low-weight babies, up to 14% of preterm deliveries, and about 10% of all infant deaths (http://www.lungusa.org/tobacco/pregnancy_ factsheet99.html). Both active (Stillman ...
متن کاملEvaluation of OECD screening tests 421 (reproduction/developmental toxicity screening test) and 422 (combined repeated dose toxicity study with the reproduction/developmental toxicity screening test).
The Advisory Committee on Existing Chemicals (BUA) of the Federal Republic of Germany convened a panel with expertise in reproductive and developmental toxicology to evaluate the OECD Screening Tests 421 (Reproduction/Developmental Toxicity Screening Test) and 422 (Combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Screening Test) with respect to their ability to...
متن کاملPredictive value of cell assays for developmental toxicity and embryotoxicity of conazole fungicides.
This paper evaluates in vivo predictability of a battery of in vitro tests covering developmental toxicity and embryotoxicity of five widely used conazole fungicides. The conazoles were investigated in the embryonic stem cell test, and data were compared to in vivo embryotoxicity data. The same conazoles were evaluated on the basis of data from a battery of cell assays for endocrine activity, i...
متن کاملA Multimedia Child Developmental Screening Checklist: Design and Validation
BACKGROUND Identifying disability early in life confers long-term benefits for children. The Taipei City Child Development Screening tool, second version (Taipei II) provides checklists for 13 child age groups from 4 months to 6 years. However, the usability of a text-based screening tool largely depends on the literacy level and logical reasoning ability of the caregivers, as well as language ...
متن کاملCAESAR models for developmental toxicity
BACKGROUND The new REACH legislation requires assessment of a large number of chemicals in the European market for several endpoints. Developmental toxicity is one of the most difficult endpoints to assess, on account of the complexity, length and costs of experiments. Following the encouragement of QSAR (in silico) methods provided in the REACH itself, the CAESAR project has developed several ...
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ژورنال
عنوان ژورنال: Birth Defects Research Part B: Developmental and Reproductive Toxicology
سال: 2014
ISSN: 1542-9733,1542-9741
DOI: 10.1002/bdrb.21132